Virtualbox6.1.18 don't work with Windows 10 (Failed to load R0 module)

[Fpedrosa]

Hello, When I try to open my Ubunto VM the Virtual machine pop up the following error:

Failed to open a session for the virtual machine UbuntuES.

Failed to load R0 module C:\Program Files\Oracle\VirtualBox/VMMR0.r0: SUP_IOCTL_LDR_OPEN failed (VERR_LDR_GENERAL_FAILURE).

Failed to load VMMR0.r0 (VERR_LDR_GENERAL_FAILURE).

Result Code: E_FAIL (0x80004005) Component: ConsoleWrap Interface: IConsole {872da645-4a9b-1727-bee2-5585105b9eed}

I have already tried to reinstall the VM software with no Success; I've tried to Disable Windows Hyper-V;

Please advise.

[Fpedrosa]

Vbox Log

[Fpedrosa]

Virtual Machine settings

[Fpedrosa]

I've also tried to create a new Virtual Machine with windows environment resulting in the same outcome...